3.5.3 Pharmacology I
Lab 5 Effect of Atrophine on Rabbit's or Guineapig's eyes (cont'd...)
Actions of Atropine on eye:
1. Persistent mydriasis
2. Unresponsiveness to light due to paralysis of circular muscles of eye
3. Relaxation of ciliary muscle followed by the paralysis of accommodation and impairment of near vision i.e. cycloplegia at overdose
4. Increase of intra-ocular pressure sometimes (should be avoided for the patients, having narrow-angle glaucoma).
Onset of action
Onset of action of the ophthalmic preparations are unknown, where as it's peak is ½ to 3 hours.
Duration of action
It is generally about 4 hours except in case it is applied topically in the eye where the action may last for 7-10 days.
Injection: .05, 0.1, 0.3, 0.4, 0.5, and 1.0 mg/mL,
Ophthalmic ointment: 1.0 % w/v, Ophthalmic solution: 0.5, 1.0, and 2.0 % w/v
Tablets: 0.4 mg.
1. Pre-operative medication (to reduce secretion, bronchodilatation)
2. Antidote for cholinesterase poisoning
3. Symptomatic Bradicardia
5. Acute iritis or uveitis
6. Cycloplegic refraction
Scale, torch, cotton whig, stop watch, dropper, a healthy rabbit, Atropine Sulphate solution (1-2% w/v).
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