3.5.3 Pharmacology I
Lab 7 Evaluation of muscle relaxation action of Diazepam using Rotarod (cont'd...)
Contra-indications: Shock, Coma, Respiratory depression, Depression, Hypersensitivity,
Amnesia, Bradycardia, CV collapse, Closed Angle Glaucoma, Acute withdrawal syndrome.
Materials: Diazepam (4 mg/kg BW), Wister rats (weighing 80-120 g), Rotarod, NS (as control),
Needle and syrringe.
The Rotarod is controlled by an advanced microprocessor, which provides precise timing control
and accurate speed regulation. Rotation can be electronically set at a constant speed using a dial on the front panel. The
animal is placed on the roller lane of the Rotarod and the timer is started. When the animal drops safely into its own lane,
the time latency to fall (minutes and seconds) and rotation speed are automatically recorded. A removable upper separator is
included to prevent interference between animals running in adjacent lanes.
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