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B.Pharm Lab. Instruction Manuals

Pharmacology I

APHE Anatomy, Physiology, and Health Education

Pharmaceutical Analysis

Pharmacy study material

Bones and Skeleton System

Bone disease (Gout) (Rheumatoid arthritis) (Osteoarthritis) (Osteoporosis)

Cancer and music therapy

Memory of water

3.5.3 Pharmacology I

Diazepam structure

Lab 7 Evaluation of muscle relaxation action of Diazepam using Rotarod (cont'd...)

Contra-indications: Shock, Coma, Respiratory depression, Depression, Hypersensitivity, Amnesia, Bradycardia, CV collapse, Closed Angle Glaucoma, Acute withdrawal syndrome.

Materials: Diazepam (4 mg/kg BW), Wister rats (weighing 80-120 g), Rotarod, NS (as control), Needle and syrringe.

Rotarod:

Rotarod

[http://www.tse-systems.com/products/behavior/motor-function/rotarod.htm]

The Rotarod is controlled by an advanced microprocessor, which provides precise timing control and accurate speed regulation. Rotation can be electronically set at a constant speed using a dial on the front panel. The animal is placed on the roller lane of the Rotarod and the timer is started. When the animal drops safely into its own lane, the time latency to fall (minutes and seconds) and rotation speed are automatically recorded. A removable upper separator is included to prevent interference between animals running in adjacent lanes.

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