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B.Pharm Lab. Instruction Manuals

Pharmacology I

APHE Anatomy, Physiology, and Health Education

Pharmaceutical Analysis

Pharmacy study material

Bones and Skeleton System

Bone disease (Gout) (Rheumatoid arthritis) (Osteoarthritis) (Osteoporosis)

Cancer and music therapy

Memory of water

3.5.3 Pharmacology I

Diazepam structure

Lab 7 Evaluation of muscle relaxation action of Diazepam using Rotarod (cont'd...)

Specifications of Rotarod for rats and mice:

Outside Dimensions-Rats

167.64 cm (H) x 91.4 cm (W) x 60.96 cm (D)

Outside Dimensions-Mice

83.82 cm (H) x 91.4 cm (W) x 60.96 cm (D)

Lane Dimension-Rats

7.5 cm

Lane Dimension-Mice

5.0 cm

Rod Diameter-Rats

9.0 cm

Rod Diameter-Mice

3.0 cm

Fall height From Rod center- Rats

121.92 cm

Fall height From Rod center- Mice

45.72 cm

Rotarod Spindle Speed-Rats

Up to 30 rpm ( by 1 rpm steps)

Rotarod Spindle Speed-Mice

Up to 22 rpm ( by 1 rpm steps)

Method: The time of falling from the rotarod is measured for each rat before the administration of the drug. Then the rats are administered diazepam (4 mg/kg BW, i.p.) and the time of falling is noted again in every 30 minutes until it becomes normal.

Result:

Sl no

Time of falling (seconds)

0 Minute

30 Minute

60 Minute

90 Minute

H





B





T





HB





HT





UM





Mean





SD





SE





q value





P value





Conclusion:

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