Dosage and monitoring tests for anti-rheumatoid drugs
Common mechanism of action
Act by inhibiting cyclooxygenase (COX) enzyme thus relief from the signs and symptoms of inflammation (redness, swelling, pain).
Major adverse drug reactions (ADRs) of NSAIDs
Gastro intestinal tract intolerance, gi ulcer, nephrotoxicity.
Monitoring test for NSAIDs
Serum creatinine (Scr) or blood urea nitrogen (BUN), complete blood count (CBC) every 2-4 weeks after starting therapy for 1-2 months; salicylates: serum salicylate levels if no response in therapeutic dose, guaiac every 6-12 months.
Doses: Adults: 2.6-5.2 g; children: 60-100 mg/kg; four times daily.
Doses: Adults: 200-400 mg once or twice daily.
Doses: Adults: 150-200 mg three to four times daily; extended release: twice daily.
Adults: 0.5-1.5 g twice daily.
Adults: 0.2-1.2 g (max, 20 mg/kg); two to four times daily.
Adults: 0.6-1.8 g ; children: 15-30 mg/kg ; two to four times daily.
Adults: 300-400 mg twice daily.
Adults: 10-20 mg once daily.