Dosage and monitoring tests for anti-rheumatoid drugs
Common mechanism of action
Act by inhibiting cyclooxygenase (COX) enzyme thus relief from the signs and symptoms of inflammation (redness, swelling, pain).
Major adverse drug reactions (ADRs) of NSAIDs
Gastro intestinal tract intolerance, gi ulcer, nephrotoxicity.
Monitoring test for NSAIDs
Serum creatinine (Scr) or blood urea nitrogen (BUN), complete blood count (CBC) every 2-4 weeks after starting therapy for 1-2 months; salicylates: serum salicylate levels if no response in therapeutic dose, guaiac every 6-12 months.
Doses: Adults: 50-200 mg; children: 2-4 mg/kg (max, 200 mg); two to four times daily; extended release: once daily.
Doses: Adults:Adults: 0.9-3 g four times daily.
Doses: Adults: 200-300 mg two to four times daily.