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B.Pharm Lab. Instruction Manuals

Pharmacology I

APHE Anatomy, Physiology, and Health Education

Pharmaceutical Analysis

Pharmacy study material

Bones and Skeleton System

Bone disease (Gout) (Rheumatoid arthritis) (Osteoarthritis) (Osteoporosis)

Cancer and music therapy

Memory of water

Gout: Cause, Diagnosis and Treatment(cont'd...)

Dosage and ADRs of acute Gouty arthritis agents

Sulindac

Dosage:200 mg twice daily for 7-10 days.

ADR: GI toxicity

Colchicine

Dosage:0.5 to 0.6 mg orally once a day for 3 to 4 days a week (less than 1 attack/year).
0.5 to 0.6 mg orally once a day (greater than 1 attack/year).
Severe cases may require 1 to 1.8 mg/day.

ADR: Oral colchicine causes dose-dependent GI adverse effects (nausea, vomiting, and diarrhoea) in 50% to 80% of patients before relief of the attack, neutropenia and axonal neuromyopathy, which may be worsened in patients taking other myopathic drugs (e.g., statins) or in those with renal insufficiency.

Prednisone

Dosage:30 to 60 mg (or an equivalent dose of another corticosteroid) orally once daily for 3 to 5 days.

ADR: Immunosuppression, joint erosion in chronic uses, rebound attacks may occur upon steroid withdrawal.

Methylprednisolone acetate

Dosage:A single intramuscular injection.

ADR: joint erosion in chronic uses.

Triamcinolone hexacetonide

Dosage:Intraarticular administration of 20 to 40 mg.

ADR: joint erosion in chronic uses.

Adrenocorticotropic hormone (ACTH) gel

Dosage:40 to 80 USP units, may be given intramuscularly every 6 to 8 ours for 2 to 3 days for patients with contraindications to first-line therapies (e.g., heart failure,chronic renal failure, history of GI bleeding).

ADR: joint erosion in chronic uses.

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